Do not attempt to engage them in melee as their fire breath does VERY high damage especially against targets that don't move, plus they explode on death.
Flashbang Grenade can also stun unprotected Klixen. Reave is highly effective against both their armor and health, and it stuns them briefly if used against their health. Stasis can stop even armored Klixen and ragdoll them briefly after it wears off.
Klixen do not possess armor on lower difficulty levels, but they compensate with high health and heavy resistance to fire from all sources they also do not panic from burning effects.
Like Husks, they will attempt to overwhelm their prey with numbers. If killed while frozen, they will simply thaw before exploding. Their fire-breathing attack can stagger the player, and their corpses will explode violently after they die. Klixen may move slowly, but they become dangerous foes at melee range.